For instance, it is really easy to entice people suffering from aging diseases into experimental medical trials. People suffering from Alzheimer’s disease are well aware that their illness is serious and that there is no specific cure available – the experimental drugs provided no guarantee – they can either make one worse or slightly alleviate the pathology.

Clinical trial on aging diseases is something that can bring great results, but there are high risks. In order words, it is easy to have someone sick to entice on human trials but will someone who is free of any aging disease be willing to participate in similar research; to find a drug for longevity (healthy aging) knowing that there might be lots of risk involved.

For instance, the famous bio-gerontologist, Aubrey de Grey, suggest that it is possible to avoid cancer by putting an end to telomere shortening; Telomeres acts as protective ends to our chromosomes and do shorten during cell division. As cells continue to divide the telomere does steadily get shorter until a point that cells can no longer divide, and turn into a state of senescent. It has been believed that telomere shortening has evolved as an evolutionary way to prevent the emergence of cancerous cells. Apparently, most of the cancer cells tend to stimulate genes that increase the length of telomere and thereafter tumors starts to populate. In fact, Agar is very positive about Aubrey De Grey’s theoretical explanation, but he also says that he would definitely not want to be the first one to undergo human trials, after mice and monkey experiments.

The SENS [Strategies for Engineered Negligible Senescence] project interest different group of people, yet clinical trials have diverse risks. Elders who are healthy wouldn’t sign-in for clinical trials when it is possible to pay other people to carry out the dirty testing. In addition, there won’t be only one ‘cure’ for aging. Currently, multiple researches are addressing various age-related damages. In the struggle to find some cures, there will definitely be a dozen of failures.

In all medical researches, it is essential to conduct as many human trials as possible. SENS suggest that soon people will be able to live healthy up to an advance age.

In the future, will the poor become the susceptible to human trials? Maybe or maybe not. Accordingly, to Agar, it is certain that extensive animal models will be used before testing on humans – still the risk is highly present. Bio-informatics enterprises need to seriously evaluate how anti-aging interventions will affect the population.

Actually, Agar’s objections are somehow outdated as telomere treatment as a cure to increase longevity is already being realized. Regulating telomere length via different pathways is curing cancers. In addition, if Aubrey de Grey’s hypothesis is right than curing cancer will even lead to longer lifespan. Treating cancer with telomere therapies might help people to live longer and healthier.

In 2010, a Harvard report found that increasing the length of telomeres in mice can significantly increase the lifespan. According to Agar, the next step in telomere research will be to involve elders who are poor. This seems, to be a fallacy indeed, as rich people seem more enthusiastic in paying and extending their own lifespan. Currently, rich people are purchasing TA-65 a drug to increase the length of telomeres.

Source: Reason, Ta-65 and PR News Wire

Anti Aging, Health And Aging, Stem cells

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Recently, a group of research from University of Pittsburgh confirmed that they had found the secret behind a rodent’s fountain of youth.

In the University, there is a colony of progeria mice; mice which have been infected with a rare disease, inducing them to die from old age after 21 days. Yet, when the researcher group took these progeria mice, which were just about to die and injected them with stem cells taken from younger and healthier cousins the dying mice recovered and stayed alive for an addition 2 to 4 weeks.

Dr. Laura Niedernhofer, lead research said that the size and lifespan of these progeria mice could be triple through this method.

It is more than a century that researchers have been using mice for medical experiments. The mice used nowadays are tweaked and engineered, sharing blood, livers as well as brain tissues of other groups of species. The Pittsburgh progeria mice are, however, quite different from human and will probably not provide an immediate answer on how to increase human longevity.

Even so, engineered or so called re-made rodents are increasingly becoming alike to human; the disparity between man and mouse are slowly vanishing. Not only are the differences fading but researchers do nowadays even have a deeper knowledge of rodents than human and any other creature found on earth. For research, rodents are indispensable.

Some History: Mice & Laboratory Research

Ostensibly, the first vaccination against cancer was done on a mouse. In addition, mice do already have treatments for baldness as well as capsules to save them from Alzheimer’s disease. Furthermore, mouse is the only animal to have been involved in hoverboard-style levitation as well, they have had their brain simulated in a computer. They were even the first non-human mammal to have had their whole genome mapped.

Everything began in 1902, when a scientist named William Castle, brought pet mice to the Harvard Genetics Laboratory, and now rodents have been the back-bone of almost all the key drug treatments as well as medical procedures used in modern medical care. According to Dr. Janet Rossant, who is the senior scientist as well as chief research at Tornoto’s SickKids Research Institute, almost all the major drugs marketed today have been the result of mouse models in developing drugs.

Statistics are surprising; in 2010, a total of 1,132,706 mice had been killed in Canadian laboratories. In any year, mice make up to 50 percent of the animals used in laboratories, and the second most commonly used animal is rats.

There are strong similarities between humans and mice. They both have immune system, circulatory systems and skeletons. In addition, mice and human can suffer from similar health predicaments such as diabetes, cancer, heart diseases, and with some minor genetic modification, mice suffer even from Alzheimer’s disease and cystic fibrosis. In laboratory terms, using mice makes sense; they are cheap, have a lifespan of 12 weeks and are easy to maintain. In other words, in the term of a single semester, several studies can be completed.

According to Dr. Michele Martin, who is a veterinary director at the University of Victoria, apparently ‘almost any disease’ you can find you will come to know that there is ‘a mouse model’ that has been used to ‘describe it’.

In 1929, the Lab Mouse Pioneer C.C. Little, Jackson Laboratory was founded, which is today’s leading supplier of so called genetically modified mice. There are more than 5,000 different strains of mice in the laboratory. The cost for a classic ‘dilute brown’ mouse, which is the oldest in the catalogue is roughly $30 a piece. It was first developed in 1909.

In the beginning mice were changed in the same way as dog breeders had changed wolves into Chihuahuas; selective inbreeding. However, in the 1980s, genetic engineering was available and since then it has been much easier to tweak and create customized mice.

In 2002, the first non-human animal, the rodent had its whole genome mapped. The mice had 99% of its gene shared with humans. This gave rise to a whole new agenda of scientific research.

In modern research, mice are no longer kept in wire-bottom cages; they are placed in large collective cages. This makes the mice happier and for research, it is better to have normal animals involved in research for more accurate results.

From 2000 to 2009, the number of mice euthanized in Canadian Laboratory experiments amounted to 10 million, which are equivalent to 3,000 mice per day.

Universities in China, Korea and Japan have an annual memorial day every year to serve homage to all animals that have been killed in research as well as experiments. The ceremony is a way for research communities to show their indebtedness to laboratory animals; as today almost every pill bottle sold in pharmacy across the globe are the result of thousands of mice.

In 1929, penicillin was first discovered, but it was only in 1940 that Oxford University could understand how penicillin worked, and it was thanks to research conducted on mice. Similarly, meningitis as well as polio vaccines are mainly a result of the lab mice.

According to Dr. Rossant, mice are ‘very, very powerful systems’ to comprehend the distinct pathways of severe diseases. Yet, lab mice are not perfect. There is a dozen of cures available for cancer which works on mice but not yet on humans. In addition, Thalidomide is a drug that caused defects to almost 10,000 children, noting that it had no negative effects on mice.

The degenerative disease, ALS, which Stephen Hawking, the theoretical physicist suffers from have various rodent-based therapies – yet – the 70 years-scientist will probably not live long enough to see the therapy available for humans.

In the 100 years that mice have been used for research, the aim has always been to change the rodent into a so called tiny human being. Nowadays, rodents have human blood, humne immune system, human organs, and they even have the bad human traits such as violence, alcoholism, drug addiction as well as gluttony.

In December 2011, the U.S Based national Institute of Health, reduced funding for additional research on chimpanzees as a progressive step to prevent research on chimpanzee. Chimps have been considered to human to have laboratory experiments justified. Several countries around the world have mirrored the widespread discontent of chimpanzee research through the so called ‘save Gabon’

Yet, mice are increasingly becoming like human, as the engineered mice aren’t really as the traditional mice.

Source: national Post

Anti Aging, Bioscience, Stem cells

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For instance, HSCs that are present in adult mammals’ bone marrow does produce all the blood cells in our body. So unveiling the secret of the origin of these cells provide an advance understanding in how embryonic stem cells can be better used to produce new blood cells, which can be utilized for blood therapies.

Speck does also act as an Investigator for the Abramson Family Cancer Research Institute and Penn. This study was recently released in the Cell Stem Cell.

According to speck, the main aim of stem-cell therapies is to inject stem cells into particular cell lineage to either substitute dead or diseased cells present both in children and adult humans. However, to be able to make this a reality, it is essential to comprehend how cells differentiate as an embryo.

In earlier studies, it was said that HSCs was derived from a minor population of cells lining blood vessels known as endothelial cells. Yet, it has been unexplained how endothelial cells could change to blood stem cells such as HSCs.

There are various stages that the embryo undergoes in the process of transiting to blood-cells. The first stage is the provision of a source of oxygen to the embryo, and the last stage is the final development of HSCs which will be present in adult bone marrow. The first phase of creating progenitors such as induced pluripotent stem cells or embryonic stem cells has successfully been done in laboratories. However, all effort and attempt to generate hematopoietic stem cells as been fruitless.

According to Speck, it is essential to understand the origin of HSCs, in order to be able to generate hematopoietic stem cells from induced pluripotent stem cells or embryonic cells.

This current study has helped haematologist to go one step ahead. Biologists are now able to produce blood cells from typical endothelial cells. These cells can equally be controlled in the embryo. However, HSCs can only be produced from particular endothelial cells. There were unique markers used to understand the sequence of how to produce HSCs. A marker, known as Ly6a when induced to endothelial cells generated HSCs while if not used other distinct waves of blood cells were produced in the first stage.

This recent discovery will support progress in research of HSCs, and this will be important in delivering effective stem-cell therapies to patients with leukemia (patients who are unable to identify appropriate donors will be able to produce HSCs from their own cells). It would also be suitable for patients with blood cancer who could have blood cells replaced with stem-cell therapies.

The research carried out by Nancy Speck, PhD, professor’s team was funded by the National Lung, Blood and heart Institute.

Source: Science Daily

Bioscience, Stem cells

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One such experiment, which slowed the aging process in mice, used a process of either flushing all the old and dead cells out of the organism.

The huge amount of caution needs to be exercised in case of experiments in mice applies. In spite of this, this study is the first of its kind, which has manually affected cell aging – whose significance has been a debatable topic among biologists for several decades – thereby introducing the scope to determine its effect in aging in humans.

The results are definitely visible, even though only a single strain of mice genes was modified. These mice were already treated in such a way that their heart would eventually be affected, hence died as pre-determined. But they definitely had much better health.

Mayo Clinic’s Darren Baker, who is a specialist in gerontology, said that the mice were healthy right until the moment of their death.

On 2nd November, the journal ‘Nature’ published the experiment of Baker and his colleague, which killed those mouse cells which produced a protein known as p16Ink4a or p16 in short.
All by itself, p16 is not the entire story. It restrains tumor. But a more important fact is that it is termed as a biomarker which indicates more to it. If a cell is found to be containing p16, there is a probability that it has attained its limit of replication, and saturation point in the process of aging.

This process of slowing down is a normal occurrence in the life cycles of cells was first brought to light by biologists Paul Moorhead and Leonard Hayflick. Incessant division of cells is tantamount to Cancer. It was suggested that cellular senescence had its own limitations by scientists in the 1990.

The cells, whose functioning was slowed down, refused to die out. If they died, they would be flushed out by tissues. On the contrary, they would just remain there, while cell-polluting substances and inflammatory proteins would ooze out of them. Abnormality in the functioning of tissues that is a result of cell-aging is believed by many researchers to lead to heart disease, cancer and other age-related disorders.

Although this hypothetical phenomenon looks apparently credible in cell cultures and samples of tissues from cadavers, living aging animals have not been tested with it.

Director of the Division of Aging Biology of the National Institute on Aging Division (which provided funds for this research), Felipe Sierra, said that ultimately what matters is the result of increasing or decreasing cellular aging in an animal. It is here that the hypothesis features, thereby making it very important.

Baker, along with Jan van Deursen, a gerontologist at the Mayo Clinic, led their team who initiated this experiment by giving rise to an unnaturally aging mice strain. Inactivation of p16 and other genes linked to cell aging in mice at the embryonic stage, led to the normal aging process.

It indicated the significance of cell-aging alright, but would have been more convincing if the treatment were given to mice who had gone through cellular aging for the majority of their lives. To demonstrate such a desired effect, a mouse strain that would age faster was designed by van Deursen and Baker. This new mouse strain could dispense cells producing p16 from eyes, fatty tissues and muscles, when treated with the drug.

After the drug was administered, the mice’s muscles ceased to release waste. There was no growth of cataracts. They were in very good health right until the time their hearts stopped functioning. These organs were not affected by the cell-aging stoppage breakthrough.

Sierra spoke about the apparent relevancy of senescence by acknowledging the part it essays in disorders brought on with age.

However, Baker and Sierra both recommended to treat with caution. Applying this phenomenon to diseased mice kept in a germ-free environment is much easier than applying it to mice that are healthy. It could give rise to hitherto unexpected effects. It was termed as ‘Proof of Principle’ by Baker and ‘Low-Hanging Fruit’ by Sierra.

University of Texas’s gerontology expert Steven Austad, who did not play any part in the research, supported these warnings. He shed light on the fact that many experiments which succeed when performed on mice turn out to be more complex than initially thought to be. In very recent times, a lifespan increasing drug, which was much touted, faced a loss of credibility when newer findings did not prove the drug to live up to its promise.

Austad said that the proof about the existence of a technology that could be used to kill cell-aging in specific tissues is the most interesting thing even more interesting in than the effect of the animal itself. He said that the way to do this has been uncovered with great difficulty, and it paves the way for much bigger developments ahead in time. This carries the rise of an ever-present query for experts – what role does cell-aging play in aging of the entire animal?

According to Sierra, results are a bit difficult to obtain as the aging process differs across different cell cultures and tissue types. For example, cells of the brain are already being tested.

Sierra said that this study of senescence has been evolving for the past five decades and the excitement is unlimited.

Source: Wired

Anti Aging, Bioscience

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Two-third of women aged more than 70, believe that breast cancer occurs more frequently in women between 40 and 59. The charitable Breast Cancer program reports that this wrong notion leads to the deaths of 12,000 women due to breast cancer, in Great Britain alone.

The reality is that, in one-third of the 48,000 breast-cancer cases detected per annum in the country, the affected women are over 70 years of age, in contrast to the common belief.

The study also revealed that only 50 per cent of women aged above 70 actually knew that they were supposed to undergo a regular breast examination by NHS. Only one woman out of seven had undergone such a test after entering the 71st year of her life. The Chief Executive of the Breast Cancer Campaign, Baroness Delyth Morgan, said that it is tremendously worrisome to know that, in spite of the well-known fact that breast cancer attacks females in the later years of their lives, only a mere 2 per cent of the entire female population realize that they are at maximum risk when being over 70. She also said that along with being aware of the factors leading to breast cancer such as alcohol consumption, obesity, lack of exercise etc, it is important to know that age is the strongest factor. Sadly, women, who fall in the age group that runs the highest risk of contracting breast cancer, are completely oblivious to this fact.

It is essential to spread awareness so that elder women know that they are highly exposed to breast cancer and should undergo screening. For the UK, this could help to reduce 15,000 cases of breast cancer of elders per year.

Source: Telegraph

Anti Aging, Gerontology

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Researchers from three different institutions have been working in collaboration to successfully show that human skin cells can be changed into brain cells, through the suppression of the availability of enzyme p53. It is a protein that is by default coded into oncogene. In other words, the research that involved Children’s hospital of Orange County (CHOC) in California, Keck School of Medicine of the University of Southern California (USC) and Good Samaritan Hospital Medical Center in New York, proposed that p53 alteration is deeply responsible for the fate of cells.

It has often been assumed that oncogenes are genes which have been mutated; so they have transformed healthy cells into bad and cancerous tumor cells.

According to the findings that were published in American Association for the Advancement of Science (AAAS), Jiang F. Zhong Ph.D., assistant professor of pathology from the Keck School says that reality seems more complex than most people suggest. It is highly possible that stem cell genes and cancer genes are one and the same thing.

Zhong said that it is believed that if p53 is suppressed, the cells will become cancerous as we tend to emphasise on damaging results. However, study showed that the cell turned more plastic, which means that there is something good in it. Let’s take an analogy of an employee who loses his job, which in our case is the suppression of p53. This individual could either turn into a criminal or he could find a second job and induce positive results into the society. Currently, we are unsure what will push the individual either ways, as our surroundings and being are highly complex.

In our body, stem cells differentiate and divide into varied categories of cells. For humans, the so called embryonic stem cells change into three categories or rather types of cells. Until now, scientists are still uncertain as to how this process of differentiation really works.

Yet, we know that these different layers of cells generate tissues and organs. For instance, the endoderm leads to the development of lungs, colon and stomach. On the other side, mesoderm layers lead to the formation of bone, blood and heart tissues. In the study carried out by Zhong’s team of researchers, human skin cells were scrutinized. Human skin cells are highly associated to neural and brain cells which are formed by ectoderm.

It was found that the suppression of p53 turned skin cells into ostensible human embryonic stem cells. In contrast to the ‘pluripotent’ cells which are man-made and can be changed into any type of body cell, these cells could only be differentiated into cells found in the same family or germ layer which is for the skin cell; ectoderm.

The induced pluripotent stem cells (IPSCs) are extremely hard to control, as they can be changed into different type of cells. However, the skin cells that were suppressed by p53, turned only into different cells in the ectoderm linage.

Zhong believes that the suppression of other types of oncogenes would generate the similar effect. The finding of the study can be proved to be highly important for the advancement of stem cell therapy.

According to Zhong, future studies might find which genes should be controlled and manipulated for various treatments.

Source: China Daily

Anti Aging, Bioscience, Stem cells

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Slowing the aging process with stabilized stem cells

A majority of people are forced to succumb to the tormenting experience of growing old and being unremittingly ill. However, scientific research shows that future regenerative medicine will be able to cure or significantly improve the health issues troubling most humans. Stem Cell 100TM moves the belief of the scientific community a step closer to reality by providing a few advantages of current stem cell treatments via a boost in the functions of adult stem cells.

As mentioned earlier, the cell therapeutic product encourages the regeneration of adult stem cells, which is effective in maintaining “normal” blood sugar, blood pressure and cholesterol levels, as well as in sustaining the health of your heart, immune system, colon, prostate, pancreas and breasts. A healthy inner body will eventually lead to a radiant skin complexion, improved focus and memory, and better stamina.

Stem Cell 100TM aims to reverse the negative effects of aging and help the body recover the regenerative ability similar to that of a child – fast, efficient mending and renewal of damaged tissues due to youthful regenerative stem cells – by “stabilizing stem cell function”. The product intends to regain a nourishing microenvironment for stem cells to improve their growth and ability to patch up damages, of which under normal circumstances, will deplete as we age.

Comparing Stem Cell 100TM with other commercial cell therapeutic products

Unlike other stem cell products in the market which accelerate or increase stem cell production, Stem Cell 100TM enhances instead, the efficiency and durability of stem cells, and at the same time, maintaining the microenvironment around them. It is deemed as a more successful stem cell treatment as the number of stem cells in a person’s body is rather inadequate, thus hastening their use in stem cell production may not be a decent approach.

The effects of Stem Cell 100TM on an animal model

Both normal and maximum life expectancy of the Drosophila (fruit fly) species was significantly prolonged during a massive experiment on Stem Cell 100TM. Six cages of fruit flies were involved in the research, of which Cages T1 to T3 were treated with Stem Cell 100TM and with Cages, C1 to C3 acting as untreated controls. Five hundred fruit flies (250 males and 250 females) were released into each enclosure at the beginning of the experiment. The end results proved that the product had “more than doubled” the average life expectancy of the Drosophila species with a 123 percent boost.

Indirectly, the study predicted the product’s ability to increase the median lifespan of mankind to 167 years. Fruit flies were used in this laboratory test due to the similarities they share with humans – a cardiovascular system with cardiac arrest being their leading cause of death, and a difficult-to-expand life expectancy. The findings surpass all other anti-aging therapies that have been previously assessed, which include genes alterations and diet control.

The fruit flies that were treated with the Stem Cell 100TM had a boast in their maximum life expectancy with 89 days, whereas the untreated controls only managed to live to a maximum of 48 days. The outcome showed an 85 percent raise in the maximum lift expectancy of fruit flies, which is the same as a person extending his life to 191 years. It is true that other possibilities may have caused the sole longest living Drosophila to survive longer, for example genetic mutation. However, the scenario was not abnormal, because several other fruit flies had managed to live nearly the same number of days. The eldest of the treated Drosophila, which constituted 5 percent of the entire group, had a 77 percent longer life than the eldest 5 percent of the untreated controls.

In addition, the research also demonstrated an enhancement in the capability of the Drosophila species to endure anxiety and disease at all life stages. The early days of the research had already depicted an obvious increase in the number of treated fruit flies that managed to live to adulthood as compared to the untreated controls.

Stem Cell 100¬TM and its four patent-pending herbal components

Stem Cell 100TM consists of elements from four important natural herbs that are commonly extracted for their active ingredients that regenerate adult stem cells and reduce inflammatory response – Astragalus membranaceus, Pterocarpus marsupium (Indian Kino tree), Pine Bark and Camellia sinesis. Polysaccharides, flavonoids, and astragalosides are extracted from Astragalus membranaceus, and are useful in maintaining stem cells, as well as the cardiovascular and immune systems. Marsupsin and pterostilbene, however, are two “stable resveratrol analogs” extracted from Pterocarpus marsupium (Indian Kino tree), which encourage stem cell growth, reduce inflammatory response and stabilize the metabolism level.

Pine Bark extracts contain Flavonoids and oligo-proanthocyanidins (OPCs), which can prevent reactive oxygen species imbalance, and lower DNA damage and inflammatory response. Camellia sinesis, which is the last of four herbs mentioned, contains a natural amino acid named L-Theanine that promotes stress and inflammation reduction, and at the same time, enhance the human learning abilities while preventing ischemic or toxic brain injury.

Potential users

Stem Cell 100TM can be consumed by the adult age group of 22 years or more. Younger users, particularly those in their 20s and 30s, will enjoy the improvement in stamina during intense exercise routines, whereas elder consumers will benefit from their noticeably healthier and energetic lives.

Source: Stem Cell 100

Anti Aging, Anti Aging Products, Anti Aging Supplements

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How is it possible for us not to notice the importance of the human body’s biggest organ? Despite its significance, the skin is not invincible. Damaged skin, particularly burn wounds that mostly involve layers of skin, will eventually expose you to potential disease and illness. Fortunately, Avita Medical is introducing a modern skin injuries treatment technology that guarantees positive results.

What’s more? This new product, which is named ReCell, is a spray! Doctors can now heal wounds and burns by spraying healthy tissue samples on the injuries.

Well, let’s clear the mystery of how these miraculous spray-on-skin functions. Burn patients or others with different dermatological needs will be treated by introducing minimal amount of unharmed skin (taken by doctors from unaffected areas) to the injuries. ReCell is more than just a spray-on-skin; it contains all necessary tools for cell harvesting and cell culture. Cell harvesting is a process vital in retrieving every cell type involved in burn and wound healing, including structural cells (fibroblasts), cells essential in skin damage repair (keratinocytes) and pigment cells (melanocytes). Besides being an edgy spray that heals, ReCell is also a promising scar-free wound treatment technology. Scars are considerably destructive, especially to a person’s outlook and confidence.

Dr. Fiona Wood, an Australian plastic surgeon that gains global recognition, initiated the theory behind ReCell in the beginning of the 1990s. Since then, the concept is consistently developed. Conventional burn healing methods normally involve skin grafting. Through this procedure, a patient will have to undergo an operation of which undamaged skin is surgically removed to be transplanted.

Cultured epithelial autograft (CEA) is yet another widespread treatment for severe skin injuries that involves healthy skin harvesting and lab work that grows the skin into “sheets” prior to its usage. It is true that both treatments are worthy life savers, but they still bear a number of problems that Avita Medical intends to tackle with ReCell.

The spray-on-skin’s exceptional wound healing speed is one of its prime benefits. As proven by researchers, wounds that require more time to recover are exposed to higher risk of disfigurement and other problems. Unlike CEA which takes a few weeks to grow ample cells for wound treatment, ReCell only needs one week or less, thus lowering the danger of massive skin deformities from about 75 percent to 4 percent. It is indeed an encouraging improvement. However, the concept of fast skin damage repair has already been introduced by technologies such as skin printers and wound powders of which both similarly promote the idea of defect organ renewal.

ReCell does share the same initiative, but uses dissimilar techniques to further enhance the theory. ReCell rids the patients of the inconvenience that skin printer users have to face – retrieving stem cells from donors – by using the patients’ healthy cells. In the case of ACell’s wound powder, wound epithelialization is promoted by speeding the patient’s own cell regeneration ability. ReCell, however, places the cells directly on an injury. It may seem that each technology boasts different advantages, and each has managed to live up to their advertised values, but further research should be conducted to match the types of injuries with their most suited treatments.

With ReCell, patients no longer need to fear the complications of surgical operations. Surgical anesthetic drugs and surgery itself have been greatly developed as compared to the olden days when anesthesia-related deaths are dreadfully common. Regardless of their improvements, certain reactions to anesthetics can still be fatal. Not to forget, patients are also at risk of several side effects. Evidently, anesthesia should be avoided when a less health-threatening substitutes are accessible. It is possible as well for ReCell to enhance existing therapies in healing children’s burns and other skin defects.

Present technology such as skin grafting or CEA does not ensure proper skin growth as the child ages. Sometimes, there is a high risk that the skin may not even grow. As a result, the child will be operated constantly until the skin matures. Such continual torture can now be avoided by using ReCell as it promotes normal skin stretching and growth.

After knowing all the advantages ReCell guarantees and its importance in the future development of wound healing treatments, you would most probably vote “yes” for the technology to be introduced immediately in the US. Shockingly, it is still awaiting approval from the food and drug administration (FDA).

A statement at Avita Medical websites states “ReCell is under clinical investigation as an investigational device and is not approved for marketing in the USA.”

The reason for the slow response of FDA is yet to be known seeing that ReCell’s success rate is very high in numerous countries, such as Australia, Germany, France, Canada and the UK. The convincing results should prove to the FDA that ReCell is a promising technology in dermatology. However, it is quite common for the FDA to take a much longer time in considering the approval of stem cell treatments and at times, the decision is rather unreasonable. Though, we should respect the laws restricting the FDA as it must be admitted that the regulations were passed by the Congress. Optimistically, the FDA will approve the spray-on-skin soon to provide an alternative to surgery.

It is still unknown how far will this amazing advancement go, and it is definitely a technological progress worth witnessing. Probably, internal organs can be treated and renewed without the presence of a donor by adapting the same theory. As the wound healing technology improves with time, treatments with better healing speed and effectiveness could become available.

Source: Singularity Hub, New South Wales Dep. Of Health, and Avita medical

Anti Aging, Bioscience, Health And Aging, Lifestyle

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This incident in fact reveals the human enhancement. Similarly there is another case of an Australian artist called Sterlac, who put an ear in his forearm. He made this his 3rd ear, in the lab.

He also wanted to put Bluetooth in his ear, so that people could hear his talk on internet; worldwide. But his wish could not be fulfilled due to infections.

Another artist, Steve Haworth has developed small magnets which he sells for a very small fee. The magnet is then implanted into your finger tips. These magnets will enable one to sense magnetic fields in the surrounding.

Similarly, Prof Kevin of cybernetics inserted a RIFD chip on his arm for opening and closing the door. This became a very controversial statement when he said that this chip should be used on dogs and cats for tracking purpose of crime, especially in murders. Such stories actually give interesting material to the media. It does also fascinate people, but it disturbs the human boundaries.

It is in human nature to keep on increasing its power through technology thus doing various experiments. Many such examples of human sense extension can be seen as imaging through the functional magnetic resonance and microscopes of atomic forces. Humans are always attracted to mysterious and weird things. As cosmetic surgery and Viagra is another such an example, perimeters raise many questions as can we be superpowers after such technology, or can we see our future by downloading our brain into a computer. This technology is good only for disabled as like heart, liver or hair implants.

There are many examples of athletes who miss some competition due to some kind of disability but what if the athlete has prosthetics enhancement. You can look at the example of the model Aimee Mullins, also an athlete with prosthetic legs. She has 12 sets for different lets for varied occasions. Such technology is equally very important for the soldiers who are permanently inured during wars.

There is a book on longevity never let me go, by Kazu Ishiguro. The story was recently issued as a movie. In this book society is shown in modern aspect where cloning is done to extend life by replacing organs. This movie is an example of human enhancement.

Many new technologies of reproduction and data regarding genes are emerging. A famous company called 23andMe, are doing reconfiguration of family and courtships concept. A prize is also provided by the foundation Methuselah, named as a new organ prize. They have secured $10 million for a new organ transplant until 2020. The basic purpose of this award is to develop new techniques for replacing organs as liver, heart, lung, pancreas and kidneys.

Longevity has become a great subject these days. New medical technology has evolved, and people are becoming more aware of natural diet. Some researchers such as Juan Enriquez of biotechnology are in favor of technologies of stem cells.

Researchers say that longevity through medicine can create a dozen of problems rangin from social, economic, demographic to emotional.

Some other research work says that the future human and his functions are dependent on ecosystem not us. A human body is a compound of medicine, prosthetics and promises, just like Alice in Wonderland. Actually human boundaries are body boundaries. The social and ethical boundaries of our species are tested by the researchers.

A question that emerges is whether we should go for enhancement or not. The easiest way might be to modify ourselves. Is longevity leaving a good effect on the planet? These are only a few reflections that people have to decide before opting for the best means to enhance human skills and extend human lifespan.

Source: Guardian.co

Anti Aging, Anti Aging Theories, Immortality, Lifestyle

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As we progress in age our stem cells lose both quality and quantity so just when we really need what these stem cells have to offer at a crucial time, we actually begin to have a deficit of these cells. Therefore, our organ function begins to suffer and we begin to experience more tissue damage that requires repair and restoration.

Additionally, just as adult stem cells aid in the restoration of our faltering organs, immune system and other maladies – these same stem cells are also capable of eventually repairing our aging skin.

The chances of rejection are slim when we utilize our own stem cells and this means there is a decreased likelihood we may need the potentially harmful immunosuppressive medications ordinarily used for these kinds of therapies. Beyond the moral, ethical and regulatory issues with embryonic stem cell treatments, adult stem cells could embrace a number of technical benefits. Number one of these is that they might be more practical in their viability.

The beauty of stem cells lies in their probable capacity to grow into numerous kinds of cell varieties. As a stem cell splits, it will become either a different type of cell – like a brain cell or muscle cell – or it stays a stem cell. Additionally, these cells work to repair interior tissues of varying types, separating what seems like an indefinite number of times in order to restore other cells.

If these stem cells could be programmed to morph into particular cell varieties, perhaps they would provide a consistent substitute supply to cells and tissue, as well as being utilized to treat illnesses such as:

• Strokes
• Burn cases
• Spinal cord trauma
• Alzheimer’s
• Heart disease
• Diabetes
• Rheumatoid arthritis and Osteoarthritis
 
Thrilling Breakthroughs Are Currently Happening

Each year we lose fifty thousand people who were in line for some type of organ transplant. Each day one hundred thousand people perish due to age associated illnesses and ailments. Would it not be incredible if we could actually replace every single organ in someone’s body with more youthful and unspoiled organs while they advance in age?

There have been measures taken of late that make this scenario appear to be much more likely. For example, a critical tuberculosis patient actually had a successful trachea transplant, utilizing her own stem cells. Medical experts from four Universities in Europe utilized a trachea from a cadaver donor, took out the cells, leaving only the extracellular composition and replenished it using stem cells taken from her bone marrow and other places.

Some other researchers have rejuvenated a deceased rat’s heart bringing it back to life by refurbishing it from a matrix, an exposed scaffold of tissue laden with the deceased rat’s cells. They removed cells from the deceased heart and used the structure leftover for the new heart. One can see where this is headed – a method of sourcing out refurbished organs for much needed transplant surgeries.

While they spend a week being cultured inside a laboratory, these cells begin to pulsate in rhythm and in just a few more days, this refurbished heart incredibly begins to pump blood!

Could Stem Cells Be The New Fountain Of Youth?

An organization known as The Maximum Life Foundation has found an up-and-coming expertise that might calibrate this kind of therapy by safeguarding each and every stem cell therapy the world over while making them much more effective.

Our cells become arbitrarily harmed or altered through time though tiny margin of them might only suffer minimal damage – or avoid it altogether. This means that some of our stem cells could be as pristine as the ones we had in our youth – or perhaps in our early childhood or infancy.

This type of knowledge base identifies isolates and augments these pure stem cells from the patient’s own group for treatment options. In theory, the outcome would be a heart patient may have their heart treated using young stem cells instead of older, altered cells which are being utilized these days – and with the potential for extremely effective results.

This is an incredibly thrilling area of medicine and it just continues to progress each day in wildly successful ways. We need to be aware of coming news and updates regarding this unbelievable form of medicine that could change the way we are treated for disease and illnesses as they relate to age progression and our longevity.

Bioscience, Health And Aging, Longevity, Stem cells

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