Designer Pharmaceuticals Are On The Way
This Drug Will Make One’s Past Memories New Again
Some drugs have been created to assist a person’s memory so they can recall what they have learned and there are drugs that conversely will erase all of a person’s memory. To this point in time, there has not been a pharmaceutical available that can actually augment and fortify the old memories that we all have dangling on the abyss of lost recall. At the present, a faction of scientific researchers studying the brain have stated that they have singled out an enzyme within the brain that will aid in the total recall of one’s long term recollections – keeping them sharply in your mind’s eye.
Scientific investigator, Reut Shema and his associates were aware that the enzyme PKMzeta assisted in the preservation of enduring memories warehoused within the brain. However, of late they revealed that enhancing the amount of PKMzeta aided a rodent’s ability to remember, with explicit accuracy, scenarios they went through quite a few days previously. When quantities of the enzyme were reduced, the rodents started to rapidly forget these memories. The extraordinary thing about their successful achievement is the fact that PKMzeta can assist animals with their recollection of prior memories when their enzyme levels were not enhanced when the memories were being experienced firsthand.
The data regarding the experimental research was printed in the Journal, Science and it states:
Shema along with his associates have exhibited that over expressing this enzyme in the narrow cortex area of the rodent brain can fortify several memories at once while improving upon recollections that took place many weeks or even months prior to the enzyme research trials.
If in fact this same therapy was able to enhance human memory, we may be seeing a method to manage age associated memory failure. It could also be a way to aid us in recollecting knowledge we were once intimately associated with but that had faded from memory over the passage of time. We can expect to read and hear much more about this amazing enzyme research as our baby boomer population continues to age.
The Ground At Easter Island Gives Up A Potential Drug Therapy To Cure Alzheimer’s Disease
A bacterial derivative has been found within the earth of Easter Island known as Rapamycin and it is believed to actually offer life extension to some mammals. There are currently a couple of autonomous research investigations that are exhibiting how it can also turn around the indicators of Alzheimer’s disease. The promise of this new drug is amazing.
The recent printing of data from a trial in the Journal of Biological Chemistry established how rodents with Alzheimer’s displayed a definitive progression of improvement with recollection and cognitive capabilities when their diets were augmented by Rapamycin. The trial was published concurrently with still one other investigation, in PLoS One, that also determined the same outcome only in a separate group of rodents.
So just how does this new remarkable medication work? Veronica Galvin, a Physiologist and author with the PLoS trial stated:
Therapies with Rapamycin reduced the amount of amyloid-beta-42 which is a primary dangerous species of molecule associated with Alzheimer’s disease. Such molecules that bind with one another are thought to have a chief part to play regarding the initial failure of memory with Alzheimer’s disease. Since we are witnessing two entirely separate outcomes with unique rodent trials for Alzheimer’s disease exhibits strong proof that Rapamycin therapies are effectual and act by modifying a rudimentary pathogenic function with Alzheimer’s disease that is widespread within each of the rodent trials. This observation shows it could be a successful therapy for Alzheimer’s disease in people, also sharing quite varied life histories as well as genetic structure.
He FDA has readily approved Rapamycin for the treatment of organ transplant rejection in patients. This is a precursor for medical professionals to begin prescribing the drug for the off label treatment of Alzheimer’s disease very soon – off labeling a practice that occurs much more often than people would think. The investigators do not know what to expect – whether the drug therapy would actually turn around the symptoms of Alzheimer’s disease or just inhibit them. However, with the disease itself becoming so widespread and adversely affecting so many, these queries may be debatable at best. This drug will be making more headlines for sure in the near future.
A Pharmaceutical That Treats Loneliness And Enhances Our Recall
Being removed from other people has a tendency to stress individuals out and gives them a tardy memory, but a new medication might soon alleviate this quandary. Scientific investigators recently managed to separate an enzyme from the brain that switches on the feeling of “loneliness” felt at a time of seclusion. Resupplying this enzyme within the brain may augment our recall while removing the stressful effects we feel when left alone for extended periods – working alone or during space travel as an example.
Scientists at the University of Illinois had a few rodents segregated from one another and observed the adaptations that occurred in their brains. As it happened, the separated mice endured lowered amounts of the brain enzyme required to manufacture a stress alleviating neurosteroid named allopregnanolone. An excerpt from the Proceedings of the National Academies of Science, the place where the scientist’s information was printed, stated the following:
The modifications in the production of allopregnanolone might be the reason for any anxiety, aggressiveness, and impairment of recollection capability that was caused by the segregation from other rodents.
The potential exists that augmenting the enzyme which aids in creating allopregnanolone might alleviate lonely feelings that activated memory impediments. That or maybe just providing allopregnanolone may cause it. Whatever the reason is more study could reveal a medication that can make it a reality for people to experience rigorous amounts of time by themselves without losing their minds.
This Medication Could Provide A Crystal Clear Visual Memory
What would it be like to be able to observe something a single time and be able to recall that memory perpetually? There would no longer be a need to ask for directions from point A to Point B. There is a team of scientific investigators who have segregated a specific protein with a capability to provide the ultra enhancement to your ability to recollect whatever it is you visibly observe.
Researchers in Spain recently reported to the Journal, Science that they happened upon a material that just might be the definitive answer to memory augmentation. The team of investigators was working on a region of the visual cortex that not much is known about. It was discovered that when they increased the development of a specific protein – RGS-14 – to that region of the visual cortex in rodents there was a considerable affect to the rodent’s capability to recall items they had looked at.
The rodents that received the increased RGS-14 were able to recollect items they saw prior to nearly to two months previous. Normally these same rodents would only be able to recall these things they saw for about an hour afterwards.
The investigators decided that this area of the visual cortex – called the layer six of region V2 – was the reason for the visible recall of these memories. If this area is removed, the rodents no longer have the capacity to recollect any item they look at.
Should this protein be able to enhance visual recall in people, the repercussions would be extraordinary. In the data provided, the investigators stated that it might be utilized as a means of enhancing memory – but this sounds like a true underestimation. One quite fascinating aspect of this is that this protein only affects the visual memory, so as discussed before it would be perfect for map guidance. It could be extremely useful for architects and design engineers who are faced with numerous visual images in their thoughts simultaneously. Can you imagine how it could be of assistance for spies?
It remains to be seen if this drug would be effective for producing a photographic memory, for instance, if one looked at a copy of some script – would they be able to recall the message perfectly? Perhaps you would only recall how the page appeared? There certainly does not appear to be any disadvantages associated with a drug of this caliber short of being able to remember everything you see would induce some kind of trauma or potential delayed problem.
A Drug That Made You A Social Risk Taker – The “Trust Me” Drug
Imagine an ability to persuade people to believe you and take a leap of faith for you with only a couple drops of a liquid secretly placed in their drink? They would not be doped or drunk and there would be no druggy like bloodshot and runny eyes – only unadulterated trust of one human for another as a result of chemical assistance. The person given the drug would have no idea they were “hit with the Micky”. A novel study recently released in the Journal Neuron described how this kind of thing could occur tomorrow, just by providing a tiny dose of substance oxytocin.
This chemical is linked too many enjoyable feelings you experience – including fundamental trust – straight to love and orgasm. Investigators from Switzerland hypothesized that those folks plying a social trust game could modify their behavior when dosed with a bit of oxytocin, due to the substance artificially augmenting their capacity to trust a person. Undeniably, they were proven correct as people who were given Oxytocin willingly gave their trust to others subsequent to them being told that these same people were in fact untrustworthy in the past. Those in the trial who were not given Oxytocin did not trust the people who were said to be untrustworthy.
Based on the published materials in Neuron it states: Through the course of the study the investigators asked the contributors to partake in a couple of games – one for trust and one for risk. Throughout the game of trust, contributors were asked to put out some money, knowing there would be another trustee of the money who would invest that money and discern whether to give the earnings back, or deceive those people and keep the money for them. During the game of risk, volunteers were told how a computer would arbitrarily determine if the money raised would be paid back or not.
The participants received either a dose of the brain substance Oxytocin [OT] or just a placebo administered as a nasal spray. The OT was their choice due to studies from other scientists stating the OT had amplified a person’s readiness to trust someone else.
Throughout the game play the participant’s brains were monitored utilizing MRI’s. This sort of analytical method works by utilizing harmless magnetic fields and radio waves to outline blood flow within areas of the brain that exhibit any brain action.
The investigators discovered during the game of trust – not the risk game – that OT decreased brain action in two areas – the amygdala that deals with fear, hazards and potential chances of social disloyalty; also a region of the striatum, a portion of the wiring that directs and regulates unforeseen behavior of reward response.
The lead author and his associates determined that what they found displayed that oxytocin affected the participant’s responses that had to do with trust. “If participants were facing social challenges like they would during the game of trust, the placebo group reacted to the response with a reduction in the ability to trust while participants who had the OT displayed no alteration of their ability to trust even though they were advised that there trial partners had not honored their trust in nearly fifty percent of the cases.”
So, what this means is essentially you now have the most frightening date rape drug one could imagine – it persuades people to trust the untrustworthy and partake in risky behavior along with them. Investigators on the other hand do not see it the same way. They believe that the chances of this drug assisting individuals with social ineptness are great and it would aid those with an inability to utilize standard levels of trust when necessary. This also sounds like a great attribute of the drug however, one can also foresee the time when oxytocin could be a staple at any frat party.
Superior Soldiers Due to Anti-Anxiety Medication?
In the near future a drug that duplicates the effect of your body’s innate self soothing mechanism could be available. There will be no feeling of being drugged up in any way. Imagine what would happen if people immediately showed no fear and did so without any adverse indicators or reactions?
A team of scientists from Europe located a ligand, or a chemical substance that attaches to molecules and is able to calm down anyone or anything that is displaying signs of anxiousness. They were able to encourage a hefty degree of anxiousness in both human and rodent subjects and when they gave them the ligand XBD173 they realized their terror settled right away. The exciting thing is that there are no addictive qualities with the medication, there is no lead time required for it to become effectual and there is no indication that it causes sleepiness o makes the subject dopey in any way.
Based on study data published by the researchers:
This discovery implies that the chemical, XBD173, may be a useful contender when utilized as a safe and rapid acting anti anxiety medication. Therapies available right now such as benzodiazepines more often than not cause adverse reactions such as sleepiness, tolerability, or withdrawal indicators subsequent to long term usage. Drugs for depression can also be used to treat anxiety though there effectiveness only becomes noticeable after a few weeks of beginning treatment. While trying to locate a new treatment method, Rainer Rupprecht and his group of associates gave XBD173 to lab rodents and noticed they did not show any alarming reactions from the outset of administering the chemical. There were no signs that the rodents had built any kind of tolerance or any unwanted reactions for that matter.
Encouraged, they set out to perform the trial on a group of healthy and strong male human participants – using a placebo section, and noticed the XBD173 caused the rapid serene behavior and no withdrawal reaction after a long term use. The researchers stated that XBD173 caused these serene effects due to its altering of the inhibitory neurotransmitter, GABA; their belief is that the chemical could well be utilized for future medical purposes.
That said there would need to be some questions answered before the broad use of this drug was promoted. Number one being is the anxiousness the same as fear? This question is relevant since the drug sounds like it would be an anti fear manager which would work directly against the human fight or flight responses. Absolutely it could be utilized as a drug to promote superior soldiers. My question is I want to understand precisely what emotions I would be muting when ingesting this chemical. Would it only make me mellower when attending a high profile function or would I be inclined to walk straight into heavy rush hour traffic since I have no fear?
What makes this drug so compelling is the fact there are no adverse reactions apparent to this point. While having a medication available that masked nervousness while maintaining acceptable levels of consciousness would be exciting, I would feel much better about it if the entire superior soldier part of it was clarified.
From A State Of Autism And Back Again – Each By Ingesting A Tablet
Do you have an assignment for work that absolutely needs to be completed but you lack the mental focus to get the job done? You need a synapse modifiable restrainer, bringing about temporary autism, so you can blank out all other activity while doing nothing but calculations and figuring for days on end. The so called autism inducers might become as trendy as Provigil among the nerd society by the end of this decade. As it happens, a team of German researchers recently proclaimed that they had indeed discovered a technique for bringing on autism and they also say they can cure it.
For the last year, scientists have shown a number of times that they can induce autism in rodents by manipulating the chemistry within their brains – then “cure” these same rodents by utilizing the same methods. These findings might lead to a situation much like that in the book by Vernor Vinge – A Deepness In The Sky – depicting humans being given a brain therapy known as “focusing” that in essence changes them into autistic personalities, making them specifics oriented people prone to obsessive behavior.
This may also lend itself to recreational autism when a person wishes to separate themselves from their screwed up emotional state and simply unplug themselves. They would move into a place where human connections are no longer important reducing others to nothing but inert objects. It is best that mankind be very careful with this one.